More than just a pun, its a reflection of the decks unerring goal to burn out opposing life totals in an inferno of attack triggers
Mechanically, this aspect of blue is expressed through cards that encourage (or force) one's opponents' to drink and abilities that trigger when they do
This makes it suited to aggro decks, but it will still be a player in Commander going forward
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Zendikar also had a minor milling theme that was cut back a bit in development (although the Hedron Crab is nothing to laugh at.) In the early days there was some doubt as to how much popularity milling has, but every time we've made a push towards an exciting milling card, the audience has been very receptive
Pramikon, Sky Rampart Pramikon, Sky Rampart shakes things up a bit and breaks parity by limiting players to only attack the opponent to their left or right